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You are here: Home / Cases / Case 6: The Chest Pain Patient With Stripes

Case 6: The Chest Pain Patient With Stripes

October 4, 2016 By John Gilbert 1 Comment

the-chest-pain-patient-with-stripes

The Patient

You are on a busy evening shift in resus. An 88 year-old man is brought in by ambulance with chest pain.

The nursing staff have recorded initial observations, obtained IV access and got an ECG whilst you referred your last patient to the medical on-call team.

The paramedics have handed over to a nurse and the triage note reads:

Patient doesn’t speak English: chest pain and collapse

Vital signs

BP 164/80 mmHg
HR 70 reg
Temp 36
RR 20/min
Sats 97%
GCS 15/15


Further history

Not much history is available from the patient but he is alert and can tell you his name. The patient’s daughter arrives shortly after him and says that he woke up in the early hours of the morning with sharp chest pain and nausea. His wife heard him collapse in the front room and he was unconscious when she found him, but he quickly became fully alert.

On direct questioning the pain was central, sharp, non-radiating and has now completely settled following the IV opioids given by the paramedics. He is nauseous but hasn’t vomited, and has no other symptoms. He has never experienced anything like this before.

He has hypertension, for which he is on regular ramipril, but no other significant past medical history. He is a lifelong non-smoker.


Initial investigations

imageImpression: Atrial fibrillation (new), widespread T wave inversion; no old ECGs available for comparison

imageImpression: Wide mediastinum, right tracheal deviation, possible left pleural effusion.

Radiology Report: ‘no change from previous film, possible left sided effusion. Please correlate clinically.’


Differential diagnosis

Aortic dissection
Acute coronary syndrome


Management plan

Analgesia as required
Serial ECGs
Bloods, including cardiac markers
CT angiogram 


Outcome

image

CT aortogram report: Aortic intramural haematoma.

You start on a labetolol infusion to maintain systolic BP <120mmHg and HR <60bpm.

The patient gets admitted to coronary care for further blood pressure control and, after a long discussion between the patient, the on-call cardiothoracic team and the cardiologists, the patient opted for conservative treatment.

Ultimately, after a 2-week stay, the patient walked out of hospital with outpatient follow-up surveillance with the cardiothoracic team.

Discussion

The patient presenting with chest pain is nothing unusual for ED docs – it’s arguably the most common presenting complaint. Especially on busy shifts, it’s very easy to anchor one’s thoughts to the more familiar pathologies – ACS, PE, pneumonia etc.

When you hear hoof beats think horses not zebras.

But, awareness of the existence of zebras (or at least Shetland ponies) is vital to avoid missing crucial diagnoses.

In the case described anti-platelet therapy and traditional NSTEMI treatment could have had catastrophic consequences.

‘Acute Aortic Syndrome’

This describes a range of life-threatening abnormalities of the aorta. These include:

  • Aortic dissection
  • Aortic atherosclerotic ulcer
  • Aortic intra-mural haematoma.

Dissection is defined as bleeding into the medial layer of the aorta through a tear/ulcer in the intima. It is the most common of the acute aortic syndromes. There is an intimal flap with the creation of a true and false lumen leading to increasing vessel size.

It can be sub-divided by anatomical location using the Stanford criteria. Type A dissections involve the ascending aorta and Type B dissections are distal to the left subclavian artery.

Type A has a significantly poorer prognosis and should always be considered for emergent operative management. Type B can often be managed medically if there are no signs of malperfusion distal to the dissection.

http://eurheartj.oxfordjournals.org/content/35/41/2873#sec-35
Reference: http://eurheartj.oxfordjournals.org/content/35/41/2873

An aortic atherosclerotic ulcer is, as the name suggests, ulceration of the intima due to atherosclerosis. The ulcer penetrates into the media and can lead to dissection formation.

Intra-mural haematoma is considered a variant of aortic dissection. There is haematoma formation as a result of rupture of the small blood vessels supplying the wall of the aorta – the vasa vasorum. There is no intimal tear, but the haematoma propagates along the medial layer of the aorta and weakens the vessel significantly.

Ultimately, an aortic intra-mural haematoma can lead to:

  • Outward rupture of the aortic wall – always fatal.
  • Inward rupture of the intima – leading to classical aortic dissection (i.e. communicating true and false lumens).

Much like typical aortic dissection, aortic intra-mural haematomas are classified according to the Stanford Criteria, and managed in a similar pattern (i.e. Type A is usually managed operatively).

The case described above was a Type A aortic intramural haematoma, but was managed conservatively – this is unusual. The patient recovered well and walked out of hospital, highlighting the fact that all patients are different and should be managed on an individual, case-by-case basis. They don’t always abide by the textbooks/guidelines!

Data from the International Registry of Aortic Dissection

Aortic dissection has a reported incidence of 6/100,000 in UK based population studies (2). Total mortality has been reported as high as 47% (1,2).

How patients present:
– Chest pain 95%
– ‘Worst ever’ chest pain 90%
– Sharp/ripping sensation 64/50% respectively
– Migrating (radiating) pain 16%
– Syncope 11%

Past medical history:
– Hypertension 72%
– Marfan’s Syndrome 5% (general population prevalence 0.01-0.0.3%)

Physical Examination:
– Aortic murmur 31%
– Pulse deficit 16%

Chest x-ray:
– Wide mediastinum 61%
– Abnormal aortic contour 49%
– Pleural effusions 19%
– Normal 12% (!)

ECG:
– Non-specific ST/T wave abnormalities 46%
– Normal 31%
– Ischaemic changes 15%

ED Management of Aortic Dissection

Medical management focuses on adequate analgesia (usually titrated opioids) and reducing shearing forces in the aorta by intensive blood pressure reduction and reduced contractility of the heart. IV agents which can be rapidly titrated such as Esmolol or Labetalol are ideal for this (3).

Urgent discussion with a cardiothoracic surgeon regarding suitability for operative management is imperative for all patients with aortic dissection.

For patients with a Type A dissection, 1 month mortality of 90% has been reported with conservative management. However, surgery carries the risk of neurological deficit and severe long-term morbidity, especially in patients over the age of 80 (4).

Summary

It is crucial to consider a broad differential diagnoses in patients presenting unwell with chest pain. With multiple patients presenting similarly on the same shift it can be easy to be anchor towards  common diagnoses, and overlook rarer underlying pathology… like acute aortic syndrome.

In cases of aortic dissection the majority of patients will have ‘classical signs’ of ripping chest pain on a backround of hypertension. However, a significant minority of cases will present atypically, with normal immediate investigations. Particularly in the elderly with very severe chest pain, try to maintain a high index of suspicion. Wrongly diagnosing ACS could be fatal.

The majority of our work in the ED will always be the ‘common stuff’, with well established protocols and pathways. The mark of a good emergency physician is the ability to approach each new patient with an open mind, and always remembering to consider the rarer pathologies (zebras) if things don’t quite fit.

FOAM Resources

Emergency medicine updates review of ACC/AHA guidelines

Life in the fast lane on acute aortic dissection

Making good decisions post on St Emlyn’s

References

1. Hagan et al. The international Registry of Acute Aortic Dissection (IRAD) JAMA. 2000; 283: 897-903

2. Howard et al. Population-Based Study of Incidence and Outcome of Acute Aortic Dissection and Premorbid Risk Factor Control: Clinical Perspective. Circulation. 2013; 127:2031-2037

3. Strayer R, Shearer P, Hermann, L. Screening, Evaluation, and Early Management of Acute Aortic Dissection in the ED. Current Cardiology Reviews, 2012, 8, 000-000 1

4. Erbel et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases. European Heart Journal. 2014,2873-2926

Filed Under: Cases, Pondering Cardiology Tagged With: aortic dissection, aortic intramural haematoma, chest pain, diagnostic anchoring, dissection

Authors

  • Adam Walker
  • Andrew Wilkinson
  • John Gilbert
  • Pondering EM

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  1. Case 6: The Chest Pain Patient With Stripes – Global Intensive Care says:
    October 5, 2016 at 8:40 am

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